Differences in attitude toward adjuvant chemotherapy between colorectal cancer survivors and the medical staff of Japanese hospitals

Int J Clin Oncol. 2015 Aug;20(4):755-60. doi: 10.1007/s10147-014-0772-5. Epub 2014 Nov 27.

Abstract

Background: Adding oxaliplatin to fluorouracil-based chemotherapy can improve the survival of patients with stage III colorectal cancer by approximately 20 %. Reportedly, cancer patients are much more likely to prefer chemotherapy than medical professionals, although there is only a very small chance of achieving benefits from treatment. However, chronic neurotoxicity may be long lasting after the administration of oxaliplatin-based chemotherapy. This study aimed to evaluate potential side effects and differences in attitude between colorectal cancer patients and medical staff regarding the risk-benefit trade-offs of chemotherapy.

Methods: Relapse-free colorectal cancer patients who received adjuvant chemotherapy, doctors, and nurses were surveyed using a questionnaire regarding the side effects of chemotherapy and hypothetical clinical scenarios to quantify gains in the risk of relapse that were deemed necessary to make chemotherapy worthwhile.

Results: Responses were obtained from 147 patients, 54 doctors, and 84 nurses. Of these, 39 % of patients and 85 % of doctors replied that moderate side effects of adjuvant chemotherapy were worthwhile to achieve an absolute gain in the risk of relapse of 10 % from a baseline of 40 %. More severe side effects, as reported by colorectal cancer patients, were not associated with the larger gains necessary to make treatment worthwhile. Seven percent of patients treated with oxaliplatin, 40 % of doctors, and 43 % of nurses replied that side effects associated with oxaliplatin-based chemotherapy were severe.

Conclusions: Doctors should consider potential heterogeneity in side effects and attitudes regarding the risk-benefit balance of adjuvant chemotherapy, and that patient perspectives should enhance shared decision-making.

MeSH terms

  • Adult
  • Aged
  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Agents / therapeutic use
  • Attitude of Health Personnel
  • Attitude to Health
  • Chemotherapy, Adjuvant / adverse effects
  • Chemotherapy, Adjuvant / psychology
  • Colorectal Neoplasms / drug therapy*
  • Colorectal Neoplasms / psychology*
  • Female
  • Humans
  • Japan
  • Male
  • Medical Staff, Hospital / psychology
  • Middle Aged
  • Nurses / psychology
  • Organoplatinum Compounds / adverse effects*
  • Organoplatinum Compounds / therapeutic use
  • Oxaliplatin
  • Prognosis
  • Quality of Life
  • Retrospective Studies
  • Risk Assessment
  • Surveys and Questionnaires
  • Survivors / psychology
  • Young Adult

Substances

  • Antineoplastic Agents
  • Organoplatinum Compounds
  • Oxaliplatin