Hypertension, cardiovascular risk factors and antihypertensive medication utilisation among HIV-infected individuals in Rakai, Uganda

Trop Med Int Health. 2015 Mar;20(3):391-6. doi: 10.1111/tmi.12443. Epub 2014 Dec 26.

Abstract

Objectives: To assess the prevalence of hypertension, elevated blood pressure and cardiovascular risk factors among HIV-positive individuals in rural Rakai District, Uganda.

Methods: We assessed 426 HIV-positive individuals in Rakai, Uganda from 2007 to 2010. Prevalence of hypertension and elevated blood pressure assessed by clinical measurement was compared to clinician-recorded hypertension in case report forms. Multiple logistic regression and z-tests were used to examine the association of hypertension and elevated blood pressure with age, sex, body mass index (BMI), CD4 cell count and antiretroviral treatment (ART) use. For individuals on antihypertensives, medication utilisation was reviewed.

Results: The prevalence of hypertension (two elevated blood pressure readings at different time points) was 8.0% (95% CI: 5.4-10.6%), and that of elevated blood pressure (one elevated blood pressure reading) was 26.3% (95% CI: 22.1-30.5%). Age ≥50 years and higher BMI were positively associated with elevated blood pressure. ART use, time on ART and CD4 cell count were not associated with hypertension. Eighty-three percent of subjects diagnosed with hypertension were on antihypertensive medications, most commonly beta-blockers and calcium channel blockers.

Conclusions: Hypertension is common among HIV-positive individuals in rural Uganda.

Keywords: HIV; Ouganda; Rakai; Uganda; VIH; hypertension prevalence; prevalencia de hipertensión; prévalence de l'hypertension; traitement; tratamiento; treatment.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Antihypertensive Agents / therapeutic use*
  • Blood Pressure / physiology
  • Body Mass Index
  • CD4 Lymphocyte Count
  • Cardiovascular Diseases / epidemiology*
  • Female
  • HIV Infections / complications*
  • HIV Infections / drug therapy
  • HIV Infections / immunology
  • HIV Infections / physiopathology
  • Humans
  • Hypertension* / drug therapy
  • Hypertension* / epidemiology
  • Logistic Models
  • Male
  • Middle Aged
  • Prevalence
  • Risk Factors
  • Rural Population / statistics & numerical data
  • Uganda / epidemiology
  • Young Adult

Substances

  • Antihypertensive Agents