Identification and characterization of genetic structures coding for carbapenemases in Enterobacteria from Central Greece

Diagn Microbiol Infect Dis. 2015 Jan;81(1):47-9. doi: 10.1016/j.diagmicrobio.2014.09.022. Epub 2014 Oct 2.

Abstract

The dissemination of carbapenemases among different species of Enterobacteriaceae was investigated in the University Hospital of Larissa, Central Greece. The presence of the isoform (Tn4401a) of the transponson carrying blaKPC-2 and 5 divergent blaVIM-carrying class I integrons, including a novel structure, suggests interspecies transfer of these mobile elements and underscores their ongoing evolution.

Keywords: Carbapenemases; Enterobacteriaceae; Genetic elements; Greece.

MeSH terms

  • Bacterial Proteins / genetics*
  • DNA Transposable Elements
  • Drug Resistance, Bacterial*
  • Drug Resistance, Multiple, Bacterial
  • Enterobacteriaceae / enzymology*
  • Enterobacteriaceae / genetics*
  • Enterobacteriaceae / isolation & purification
  • Enterobacteriaceae Infections / microbiology
  • Greece
  • Hospitals
  • Humans
  • Integrons
  • Molecular Sequence Data
  • Polymerase Chain Reaction
  • beta-Lactamases / genetics*

Substances

  • Bacterial Proteins
  • DNA Transposable Elements
  • beta-Lactamases
  • carbapenemase

Associated data

  • GENBANK/KF850517