Microcirculatory perfusion and vascular reactivity are altered in post cardiac arrest patients, irrespective of target temperature management to 33 °C vs 36 °C

Matty Koopmans; Michael A Kuiper; Henrik Endeman; Gerke Veenstra; Namkje A R Vellinga; Rien de Vos; E Christiaan Boerma

doi:10.1016/j.resuscitation.2014.09.025

Microcirculatory perfusion and vascular reactivity are altered in post cardiac arrest patients, irrespective of target temperature management to 33 °C vs 36 °C

Resuscitation. 2015 Jan:86:14-8. doi: 10.1016/j.resuscitation.2014.09.025. Epub 2014 Oct 18.

Authors

Matty Koopmans¹, Michael A Kuiper², Henrik Endeman³, Gerke Veenstra², Namkje A R Vellinga², Rien de Vos⁴, E Christiaan Boerma²

Affiliations

¹ Medical Center Leeuwarden, Department of Intensive Care, Leeuwarden, The Netherlands. Electronic address: matty.koopmans@gmail.com.
² Medical Center Leeuwarden, Department of Intensive Care, Leeuwarden, The Netherlands.
³ Onze Lieve Vrouwe Gasthuis, Department of Intensive Care, Amsterdam, The Netherlands.
⁴ Academic Medical Center, Department Epidemiologic, Biostatistics and Bioinformatics, Amsterdam, The Netherlands.

PMID: 25449350
DOI: 10.1016/j.resuscitation.2014.09.025

Abstract

Aim: In previous reports both microcirculatory alterations and impaired vascular reactivity have been described in post cardiac arrest patients treated with mild therapeutic hypothermia. As of now it is unknown whether these alterations are related to the temperature management or to the cardiac arrest itself. Aim of the present study was to investigate the potential difference in microcirculatory alterations and vascular reactivity in comatose patients after out of hospital cardiac arrest treated with target temperature management of 33 °C (TTM33) in comparison to patients treated with 36 °C (TTM36).

Methods: Our study was designed as a predefined substudy of the open label randomized controlled TTM trial in 2 Dutch mixed ICU's. Sublingual microvascular flow index (MFI) was assessed by Side Stream Darkfield imaging and vascular reactivity at the thenar region of the hand by near infrared spectroscopy. Variables, including systemic hemodynamics were recorded at start study (T1), after 12h (T2) and after 24h (T3).

Results: 22 patients were included, 13 in TTM33 and 9 in TTM36. At T1 MFI between groups did not differ significantly (1.08 [0.4-1.9] versus 1.67 [0.7-2.4] respectively, p = 0.59). The difference between groups remained insignificant over time. At T1 tissue oxygenation (StO2) was significantly lower in TTM36 in comparison to TTM33: (44.6 ± 15.8 versus 58.9 ± 13.5, p = 0.03). Over time this difference between groups disappeared. However, vascular reactivity, expressed as the descending and ascending slope of StO2 after a standardized ischemic occlusion test was similar between groups.

Conclusions: In this relatively small sample size study microcirculatory blood flow and vascular reactivity did not differ nor change between TTM33 and TTM36.

Trial registration: ClinicalTrials.gov NCT01850485.

Keywords: Cardiac arrest; Microcirculation; Target temperature management; Vascular reactivity.

Publication types

Comparative Study
Randomized Controlled Trial

MeSH terms

Aged
Blood Vessels / physiopathology*
Female
Humans
Hypothermia, Induced* / methods
Male
Microcirculation*
Middle Aged
Out-of-Hospital Cardiac Arrest / physiopathology*
Out-of-Hospital Cardiac Arrest / therapy*
Regional Blood Flow
Temperature

Associated data

ClinicalTrials.gov/NCT01850485