Dynamics of proton diffusion within the hydration layer of phospholipid membrane

Biochemistry. 1989 Apr 4;28(7):2936-40. doi: 10.1021/bi00433a029.

Abstract

The diffusion of protons at the immediate vicinity of (less than 10 A from) a phospholipid membrane is studied by the application of the laser-induced proton pulse. A light-sensitive proton emitter (8-hydroxypyrene-1,3,6-trisulfonate) was trapped exclusively in the hydration layers of multilamellar vesicles made of egg phosphatidylcholine, and the protons were dissociated by a synchronizing laser pulse. The recombination of the proton with pyranin anion was monitored by time-resolved spectroscopy and analyzed by a diffusion-controlled formalism. The measured diffusion coefficient is only slightly smaller than the diffusion coefficient of proton in bulk water. Modulating the width of the hydration layer by external pressure had a direct effect on the diffusibility of the proton: the narrower the hydration layer, the slower is the diffusion of protons.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Arylsulfonates
  • Fluorescent Dyes
  • Kinetics
  • Lasers
  • Liposomes*
  • Phosphatidylcholines*
  • Protons

Substances

  • Arylsulfonates
  • Fluorescent Dyes
  • Liposomes
  • Phosphatidylcholines
  • Protons
  • pyranine