Luminal signaling: it's what's on the inside that counts

Jennifer M Symonds; Matthew P Hoffman

doi:10.1016/j.devcel.2014.11.019

Luminal signaling: it's what's on the inside that counts

Dev Cell. 2014 Dec 8;31(5):519-20. doi: 10.1016/j.devcel.2014.11.019.

Authors

Jennifer M Symonds¹, Matthew P Hoffman²

Affiliations

¹ Matrix and Morphogenesis Section, NIDCR, NIH, Bethesda, MD 20892, USA.
² Matrix and Morphogenesis Section, NIDCR, NIH, Bethesda, MD 20892, USA. Electronic address: mhoffman@mail.nih.gov.

PMID: 25490261
DOI: 10.1016/j.devcel.2014.11.019

Abstract

During organogenesis, FGFs are diffusible communication signals that allow cells to coordinate morphogenesis and establish tissue architecture. Recently in Nature, Durdu et al. (2014) show that epithelial cell clusters secrete FGFs into a microlumen, restricting FGF localization so that participating cells coordinate differentiation and collective migration via luminal signaling.

Publication types

Research Support, N.I.H., Intramural
Comment

MeSH terms

Animals
Cell Communication*
Organogenesis*
Signal Transduction*
Zebrafish / embryology*

Grants and funding

Intramural NIH HHS/United States