Antiproliferative activity of synthetic fatty acid amides from renewable resources

Bioorg Med Chem. 2015 Jan 15;23(2):340-7. doi: 10.1016/j.bmc.2014.11.019. Epub 2014 Nov 29.

Abstract

In the work, the in vitro antiproliferative activity of a series of synthetic fatty acid amides were investigated in seven cancer cell lines. The study revealed that most of the compounds showed antiproliferative activity against tested tumor cell lines, mainly on human glioma cells (U251) and human ovarian cancer cells with a multiple drug-resistant phenotype (NCI-ADR/RES). In addition, the fatty methyl benzylamide derived from ricinoleic acid (with the fatty acid obtained from castor oil, a renewable resource) showed a high selectivity with potent growth inhibition and cell death for the glioma cell line-the most aggressive CNS cancer.

Keywords: Glioma; Multidrug resistance; Ovarian cancer; Ricinoleic acid.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amides / chemical synthesis
  • Amides / chemistry*
  • Amides / pharmacology
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Drug Resistance, Neoplasm
  • Drug Screening Assays, Antitumor
  • Fatty Acids / chemistry*
  • Humans
  • MCF-7 Cells
  • Ricinoleic Acids / chemistry
  • Structure-Activity Relationship

Substances

  • Amides
  • Fatty Acids
  • Ricinoleic Acids
  • ricinoleic acid