IgA deficiency in wolves from Canada and Scandinavia

Marcel Frankowiack; Mia Olsson; H Dean Cluff; Alina L Evans; Lars Hellman; Johan Månsson; Jon M Arnemo; Lennart Hammarström

doi:10.1016/j.dci.2014.12.009

IgA deficiency in wolves from Canada and Scandinavia

Dev Comp Immunol. 2015 May;50(1):26-8. doi: 10.1016/j.dci.2014.12.009. Epub 2014 Dec 18.

Authors

Marcel Frankowiack¹, Mia Olsson¹, H Dean Cluff², Alina L Evans³, Lars Hellman⁴, Johan Månsson⁵, Jon M Arnemo⁶, Lennart Hammarström⁷

Affiliations

¹ Division of Clinical Immunology (F79), Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital, SE-14186 Huddinge, Sweden.
² Department of Environment and Natural Resources, Government of the Northwest Territories, Yellowknife, Northwest Territories, Canada.
³ Department of Forestry and Wildlife Management, Faculty of Applied Ecology and Agricultural Sciences, Hedmark University College, Campus Evenstad, NO-2418 Elverum, Norway.
⁴ Department of Cell and Molecular Biology, Uppsala University, SE-75124 Uppsala, Sweden.
⁵ Department of Ecology, Faculty of Natural Resources and Agricultural Sciences, Swedish University of Agricultural Sciences, SE-730 91 Grimsö, Riddarhyttan, Sweden.
⁶ Department of Forestry and Wildlife Management, Faculty of Applied Ecology and Agricultural Sciences, Hedmark University College, Campus Evenstad, NO-2418 Elverum, Norway; Department of Wildlife, Fish and Environmental Studies, Faculty of Forest Sciences, Swedish University of Agricultural Sciences, SE-901 83 Umeå, Sweden.
⁷ Division of Clinical Immunology (F79), Department of Laboratory Medicine, Karolinska Institute at Karolinska University Hospital, SE-14186 Huddinge, Sweden. Electronic address: lennart.hammarstrom@ki.se.

PMID: 25530092
DOI: 10.1016/j.dci.2014.12.009

Abstract

Immunoglobulin A deficiency (IgAD) is the most common primary immunodeficiency in both humans and selected breeds of domestic dogs. In both species, IgAD is associated with recurrent infections and immune mediated diseases. Previous results imply that IgAD is also common in the wild ancestor of domestic dogs, the gray wolf. Here, we report that serum IgA concentrations are significantly different in Scandinavian and Canadian wolves (p = 3.252e-15) with an increased prevalence for IgAD in Scandinavian wolves (60%), which is as high as those found in high-risk dog breeds.

Keywords: Dog; IgA deficiency; Serum IgA concentrations; Wolf.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Canada
IgA Deficiency / blood
IgA Deficiency / epidemiology
IgA Deficiency / genetics
IgA Deficiency / veterinary*
Scandinavian and Nordic Countries
Wolves / blood*
Wolves / classification
Wolves / genetics