Identification of C-type isolectins in the venom of the scorpionfish Scorpaena plumieri

Toxicon. 2015 Mar:95:67-71. doi: 10.1016/j.toxicon.2015.01.004. Epub 2015 Jan 7.

Abstract

Chemical analyses of the hemagglutinating fraction from Scorpaena plumieri venom revealed that it contains five components (Sp-CL 1-5) with similar chromatographic elution profiles (35-38% of acetonitrile), molecular masses (16,800-17,000 Da) and N-terminal sequences, suggesting that they are isoforms of the same protein. The amino acid sequence of Sp-CL4 was determined and shown to have homology with fish C-type lectins. These data demonstrate for the first time the presence of C-type isolectins in a scorpionfish venom.

Keywords: C-type lectin; Fish venom; Hemagglutination; Isolectins; Scorpaena plumieri; Scorpionfish.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Beta-Globulins / chemistry
  • Beta-Globulins / isolation & purification
  • Fish Venoms / chemistry*
  • Fish Venoms / isolation & purification
  • Lectins / chemistry
  • Lectins / isolation & purification*
  • Lectins, C-Type / chemistry
  • Lectins, C-Type / isolation & purification
  • Molecular Sequence Data
  • Molecular Weight
  • Perciformes*
  • Sequence Alignment

Substances

  • Beta-Globulins
  • Fish Venoms
  • Lectins
  • Lectins, C-Type
  • hemagglutination enhancing factor