Laboratory identification of donor-derived coxsackievirus b3 transmission

Am J Transplant. 2015 Feb;15(2):555-9. doi: 10.1111/ajt.12986. Epub 2015 Jan 12.

Abstract

Unexpected donor-to-recipient infectious disease transmission is an important, albeit rare, complication of solid organ transplantation. Greater work and understanding about the epidemiology of these donor-derived transmissions is continually required to further mitigate this risk. Herein we present the first reported case of proven donor-derived transmission of coxsackievirus serogroup-3, an enterovirus, following solid organ transplant. Swift and effective communication between the organ donation agency, treating physicians, laboratory testing and notification ensured a coordinated approach. The resulting clinical syndromes in the organ recipients were mild. This case highlights the requirement for ongoing surveillance over a broad range of infecting pathogens that may present as a donor-derived infection.

Keywords: Clinical research/practice; donors and donation: donor-derived infections; infection and infectious agents; infectious disease; viral.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biopsy
  • Coxsackievirus Infections / transmission*
  • Enterovirus B, Human / isolation & purification
  • Enterovirus B, Human / pathogenicity*
  • Humans
  • Kidney / pathology
  • Kidney / virology
  • Kidney Transplantation*
  • Liver / pathology
  • Liver / virology
  • Liver Transplantation*
  • Lung / pathology
  • Lung / virology
  • Lung Transplantation*
  • Pancreas / pathology
  • Pancreas / virology
  • Pancreas Transplantation*
  • Tissue Donors*
  • Transplant Recipients