Rhodium(III)-catalyzed C-H activation and intermolecular annulation with terminal alkynes: from indoles to carbazoles

Chem Commun (Camb). 2015 Feb 18;51(14):2925-8. doi: 10.1039/c4cc09823d.

Abstract

Herein we disclose the first example of Rh(iii)-catalyzed intermolecular annulation of indoles with terminal alkynes to give highly efficient one-pot access to privileged carbazoles. The mild reaction features moderate to good yields, exclusive regioselectivity, broad substrate scope, and excellent functional group tolerance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkynes / chemistry*
  • Carbazoles / chemistry*
  • Carbon / chemistry*
  • Catalysis
  • Hydrogen / chemistry*
  • Indoles / chemistry*
  • Rhodium / chemistry*
  • Stereoisomerism
  • Substrate Specificity

Substances

  • Alkynes
  • Carbazoles
  • Indoles
  • Carbon
  • Hydrogen
  • Rhodium