High respiratory virus oropharyngeal carriage rate during Kingella kingae osteoarticular infections in children

Future Microbiol. 2015;10(1):9-14. doi: 10.2217/fmb.14.117.

Abstract

Aim: Kingella kingae osteoarticular (KKO) infections are frequently associated with upper respiratory tract infections. However, no comparative studies detecting respiratory viruses had ever been performed between KKO and non-KKO (NKO).

Patients & methods: Eighteen viruses were searched by FilmArray(®) Respiratory Panel (BioFire Diagnostics, UT, USA) in the oropharynx of 6-to-48-month-children admitted for KKO and NKO in 2013.

Results: At least one virus was detected in the oropharynx of 19/21 (90.5%) KKO and 3/8 (37.5%) NKO cases (p = 0.008). In KKO group, human rhinovirus was predominant (12/21; 57.1%), especially during winter (7/11; 63.6%) despite its low concomitant circulation (<10%). Human rhinovirus was found in 2/8 (25%) in NKO group.

Conclusion: Higher prevalence of respiratory virus in oropharynx was observed in KKO than NKO, strengthening their putative role in KKO pathophysiology.

Keywords: Kingella kingae; PCR; human rhinovirus; osteoarticular infection; respiratory virus; upper respiratory tract infection.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arthritis, Infectious / microbiology*
  • Bone Diseases, Infectious / microbiology*
  • Carrier State / epidemiology
  • Child, Preschool
  • Humans
  • Infant
  • Kingella kingae / isolation & purification*
  • Microbial Interactions
  • Neisseriaceae Infections / microbiology*
  • Oropharynx / microbiology
  • Oropharynx / virology*
  • Picornaviridae Infections / epidemiology*
  • Prevalence
  • Respiratory Tract Infections / epidemiology*
  • Respiratory Tract Infections / microbiology
  • Respiratory Tract Infections / virology
  • Rhinovirus / isolation & purification*