Increased left atrial size is associated with reduced atrial stiffness and preserved reservoir function in athlete's heart

Int J Cardiovasc Imaging. 2015 Apr;31(4):699-705. doi: 10.1007/s10554-015-0600-7. Epub 2015 Jan 28.

Abstract

Left atrial (LA) fibrosis with increased stiffness has been assumed to be the substrates for occurrence of atrial arrhythmias in athletes. However, this hypothesis has not yet been confirmed in humans. Aim of this study was, therefore, to assess LA remodeling and stiffness in competitive athletes. 150 competitive athletes and 90 age and sex-matched sedentary subjects were analyzed by speckle-tracking echocardiography to measure peak atrial longitudinal strain (PALS) and peak atrial contraction strain (PACS). LA stiffness was determined using E/e' ratio in conjunction with PALS. Left ventricular (LV) stiffness was also calculated. LA volume index was greater in athletes as compared with controls (24.6 ± 7.3 vs. 18.4 ± 7.8 mL/m(2), p < .0001). LA PALS, LA PACS, and E/e' ratio were lower in athletes in comparison with controls (p < .05, p ≤ .001, and p < .0001, respectively). Despite greater LA size, competitive athletes had lower LA stiffness as compared with controls (0.13 ± 0.04 vs. 0.16 ± 0.06, p ≤ .001). In addition, LV stiffness was lower in athletes (0.84 ± 0.27 vs. 1.07 ± 0.46, p ≤ .001). The only independent predictor of LA stiffness was LV stiffness (β = 0.46, p < .0001), while the only independent predictor of LA volume index was LV end-systolic volume index (β = 0.25, p = .002). Competitive athletes showed greater LA size associated with lower stiffness as compared with controls. Thus, LA remodeling in the context of the athlete's heart is not associated with increased LA stiffness. These findings support the benign nature of LA remodeling in athletes, occurring as a physiological adaptation to exercise conditioning.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptation, Physiological
  • Adolescent
  • Adult
  • Atrial Function, Left*
  • Atrial Remodeling*
  • Cardiomegaly, Exercise-Induced*
  • Case-Control Studies
  • Echocardiography, Doppler, Pulsed
  • Elasticity
  • Exercise / physiology*
  • Female
  • Heart Atria / diagnostic imaging
  • Humans
  • Male
  • Myocardial Contraction*
  • Sedentary Behavior
  • Stress, Mechanical
  • Ventricular Function, Left
  • Young Adult