Heck coupling using a vinyliodo-MIDA boronate: an efficient and modular access to polyene frameworks

Org Lett. 2015 Feb 20;17(4):948-51. doi: 10.1021/acs.orglett.5b00042. Epub 2015 Feb 2.

Abstract

A simple Heck coupling between an alkenyl iodo-boronate and a variety of terminal olefins is disclosed. This method gives access to a wide range of dienic moieties including valuable bis-functionalized dienes. The synthetic potential of the coupling reaction is demonstrated by a short and modular preparation of several tetraenic compounds.