TGFβR1 inhibition blocks the formation of stenosis in tissue-engineered vascular grafts

J Am Coll Cardiol. 2015 Feb 10;65(5):512-4. doi: 10.1016/j.jacc.2014.08.057.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Benzamides / pharmacology
  • Benzamides / therapeutic use*
  • Blood Vessel Prosthesis* / trends
  • Constriction, Pathologic / pathology
  • Constriction, Pathologic / prevention & control*
  • Dioxoles / pharmacology
  • Dioxoles / therapeutic use*
  • Humans
  • Mice
  • Mice, Inbred C57BL
  • Polyglycolic Acid / administration & dosage
  • Protein Serine-Threonine Kinases / antagonists & inhibitors*
  • Receptor, Transforming Growth Factor-beta Type I
  • Receptors, Transforming Growth Factor beta / antagonists & inhibitors*
  • Tissue Engineering / methods*

Substances

  • 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide
  • Benzamides
  • Dioxoles
  • Receptors, Transforming Growth Factor beta
  • Polyglycolic Acid
  • Protein Serine-Threonine Kinases
  • Receptor, Transforming Growth Factor-beta Type I