A multiple gadolinium complex decorated fullerene as a highly sensitive T(1) contrast agent

Lirong Wang; Xianglong Zhu; Xingyan Tang; Changqiang Wu; Zijian Zhou; Chengjie Sun; Shun-Liu Deng; Hua Ai; Jinhao Gao

doi:10.1039/c5cc00285k

A multiple gadolinium complex decorated fullerene as a highly sensitive T(1) contrast agent

Chem Commun (Camb). 2015 Mar 14;51(21):4390-3. doi: 10.1039/c5cc00285k.

Authors

Lirong Wang¹, Xianglong Zhu, Xingyan Tang, Changqiang Wu, Zijian Zhou, Chengjie Sun, Shun-Liu Deng, Hua Ai, Jinhao Gao

Affiliation

¹ State Key Laboratory of Physical Chemistry of Solid Surfaces, The Key Laboratory for Chemical Biology of Fujian Province and Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China. jhgao@xmu.edu.cn.

PMID: 25676633
DOI: 10.1039/c5cc00285k

Abstract

We report a simple strategy to construct a multiple gadolinium complex decorated fullerene (CGDn) as an enhanced T1 contrast agent. The CGDn exhibits much higher T1 relaxivity (∼49.7 mM(-1) s(-1)) than individual Gd-DOTA, and shows excellent T1 contrast enhancement ability both in vitro and in vivo.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Contrast Media / chemistry*
Coordination Complexes / chemistry*
Fullerenes / chemistry*
Gadolinium / chemistry*
Heart / diagnostic imaging
Heterocyclic Compounds / chemistry
Magnetic Resonance Imaging
Organometallic Compounds / chemistry
Radiography
Rats
Rats, Sprague-Dawley

Substances

Contrast Media
Coordination Complexes
Fullerenes
Heterocyclic Compounds
Organometallic Compounds
gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate
Gadolinium