Abstract
Gargantulide A (1), an extremely complex 52-membered macrolactone, was isolated from Streptomyces sp. A42983 and displayed moderate activity against MRSA. The planar structure of 1 was determined using 2D NMR, and its stereochemistry was partially established on the basis of NOESY correlations, J-based configuration analysis, and Kishi's universal NMR database.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Anti-Bacterial Agents / chemistry
-
Anti-Bacterial Agents / isolation & purification*
-
Anti-Bacterial Agents / pharmacology*
-
Candida albicans / drug effects
-
Clostridium / drug effects
-
Drug Resistance, Bacterial / drug effects
-
Macrolides / chemistry
-
Macrolides / isolation & purification*
-
Macrolides / pharmacology*
-
Methicillin-Resistant Staphylococcus aureus / drug effects
-
Microbial Sensitivity Tests
-
Molecular Structure
-
Nuclear Magnetic Resonance, Biomolecular
-
Saccharomyces cerevisiae / drug effects
-
Streptococcus pneumoniae / drug effects
-
Streptomyces / chemistry*
-
Vancomycin / pharmacology
Substances
-
Anti-Bacterial Agents
-
Macrolides
-
gargantulide A
-
Vancomycin