Platelet-to-lymphocyte ratio is a marker of poor prognosis in patients with diabetes mellitus and ST-elevation myocardial infarction

Biomark Med. 2015;9(3):199-207. doi: 10.2217/bmm.14.100.

Abstract

Aim: Platelet-to-lymphocyte ratio (PLR) has emerged as a strong marker of worse outcomes. We determined the association between PLR and clinical outcomes in patients with diabetes mellitus and ST-elevation myocardial infarction.

Methods: Five hundred and twenty three patients were enrolled. Low PLR (group 1, n = 349) was defined as ≤ 124 and high PLR (group 2, n = 174) as >124.

Results: In-hospital and 1-year mortality was higher in group 2. Receiver operating characteristic analysis revealed moderate diagnostic value in predicting in-hospital (PLR cut-off >155) and long-term (PLR cut-off >146) death. PLR remained an independent risk factor of early and late mortality.

Conclusion: PLR proved to have good prognostic value for in-hospital and late mortality. PLR cut-off value for predicting in-hospital mortality was higher to that predicting late mortality. PLR remained an independent risk factor early and late mortality.

Keywords: diabetes mellitus; myocardial infarction; platelet-to-lymphocyte ratio; prognosis.

MeSH terms

  • Diabetes Mellitus / blood*
  • Diabetes Mellitus / diagnosis*
  • Diabetes Mellitus / physiopathology
  • Electrocardiography*
  • Female
  • Humans
  • Kaplan-Meier Estimate
  • Lymphocyte Count
  • Male
  • Middle Aged
  • Myocardial Infarction / blood*
  • Myocardial Infarction / diagnosis*
  • Myocardial Infarction / physiopathology
  • Platelet Count
  • Prognosis