Charting a map through the cellular reprogramming landscape

Lu Wen; Fuchou Tang

doi:10.1016/j.stem.2015.02.010

Charting a map through the cellular reprogramming landscape

Cell Stem Cell. 2015 Mar 5;16(3):215-6. doi: 10.1016/j.stem.2015.02.010.

Authors

Lu Wen¹, Fuchou Tang²

Affiliations

¹ Biodynamic Optical Imaging Center, School of Life Sciences, Peking University, Beijing 100871, China. Electronic address: wenlu.wl@gmail.com.
² Biodynamic Optical Imaging Center, School of Life Sciences, Peking University, Beijing 100871, China. Electronic address: tangfuchou@pku.edu.cn.

PMID: 25748926
DOI: 10.1016/j.stem.2015.02.010

Abstract

Analysis of the molecular mechanisms underlying somatic cell reprogramming into iPSCs is hampered by low efficiency of conversion and resulting cellular heterogeneity. In this issue of Cell Stem Cell, Zunder et al. (2015) utilize mass cytometry to perform high-throughput, single-cell analyses and provide a detailed molecular roadmap of the reprogramming process.

Publication types

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MeSH terms

Animals
Antigens, Differentiation*
Cellular Reprogramming Techniques*
Humans
Image Cytometry / methods*
Induced Pluripotent Stem Cells*
Transcription Factors*

Substances

Antigens, Differentiation
Transcription Factors