Vitamin D receptor genetic polymorphisms are associated with PSA level, Gleason score and prostate cancer risk in African-American men

Emmanuel Y Jingwi; Muneer Abbas; Luisel Ricks-Santi; Danyelle Winchester; Desta Beyene; Agnes Day; Tammey J Naab; Olakunle O Kassim; Georgia M Dunston; Robert L Copeland Jr; Yasmine M Kanaan

Vitamin D receptor genetic polymorphisms are associated with PSA level, Gleason score and prostate cancer risk in African-American men

Anticancer Res. 2015 Mar;35(3):1549-58.

Authors

Affiliations

¹ Cancer Center, Howard University, Washington, DC, U.S.A.
² Department of Microbiology, Howard University, Washington, DC, U.S.A. Department of National Human Genome Center, Howard University, Washington, DC, U.S.A.
³ Cancer Research Center, Hampton University, Hampton, VA, U.S.A.
⁴ Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, U.S.A.
⁵ Cancer Center, Howard University, Washington, DC, U.S.A. Department of Biochemistry, Howard University, Washington, DC, U.S.A.
⁶ Department of Pathology, Howard University, Washington, DC, U.S.A.
⁷ Department of Microbiology, Howard University, Washington, DC, U.S.A.
⁸ Department of Pharmacology, Howard University, Washington, DC, U.S.A.
⁹ Cancer Center, Howard University, Washington, DC, U.S.A. Department of Microbiology, Howard University, Washington, DC, U.S.A. ymkanaan@howard.edu.

PMID: 25750310
PMCID: PMC4743656

Abstract

Background/aim: Several studies have revealed an association between single nucleotide polymorphisms (SNPs) in the VDR gene and prostate cancer (PCa) risk in European and Asian populations. To investigate whether VDR SNPs are associated with PCa risk in African-American (AA) men, nine VDR SNPs were analyzed in a case-control study.

Materials and methods: Multiple and binary logistic regression models were applied to analyze the clinical and genotypic data.

Results: rs731236 and rs7975232 were significantly associated with PCa risk (p<0.05). In the analysis of clinical phenotypes, rs731236, rs1544410 and rs3782905 were strongly associated with high PSA level (p<0.05), whereas rs1544410 and rs2239185 showed a statistically significant association with high Gleason score (p<0.05). Haplotype analysis revealed several VDR haplotypes associated with PCa risk. Additionally, a trend existed, where as the number of risk alleles increased in the haplotype, the greater was the association with risk (p-trend=0.01).

Conclusion: These results suggest that the VDR SNPs may be associated with PCa risk and other clinical phenotypes of PCa in AA men.

Keywords: African-American; SNP; clinical phenotype; prostate cancer; vitamin D receptor.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Aged
Black or African American / genetics*
Case-Control Studies
Genetic Predisposition to Disease*
Haplotypes
Humans
Male
Middle Aged
Neoplasm Grading
Polymorphism, Single Nucleotide*
Prostate-Specific Antigen / blood*
Prostatic Neoplasms / blood
Prostatic Neoplasms / genetics*
Prostatic Neoplasms / pathology
Receptors, Calcitriol / genetics*
Risk

Substances

Receptors, Calcitriol
Prostate-Specific Antigen

Grants and funding

G12 MD007597/MD/NIMHD NIH HHS/United States