1 Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America; Africa Centre for Health and Population Studies, University of KwaZulu-Natal, Mtubatuba, South Africa.
2 Department of Global Health and Society, Harvard Medical School, Boston, Massachusetts, United States of America.
3 Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, United States of America.
Till Bärnighausen and colleagues respond to comments by the HPTN 071 (PopART) Study Team, noting the distinction between the different HIV prevention questions the trial will attempt to answer.