Post-transplant molecularly defined Burkitt lymphomas are frequently MYC-negative and characterized by the 11q-gain/loss pattern

Haematologica. 2015 Jul;100(7):e275-9. doi: 10.3324/haematol.2015.124305. Epub 2015 Mar 20.
No abstract available

Keywords: 11q; Burkitt lymphoma; PTLD; post-transplant lymphoproliferative disease.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 1-Alkyl-2-acetylglycerophosphocholine Esterase / genetics
  • 1-Alkyl-2-acetylglycerophosphocholine Esterase / metabolism
  • Adolescent
  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols*
  • B-Lymphocytes / metabolism
  • B-Lymphocytes / pathology
  • Burkitt Lymphoma / drug therapy
  • Burkitt Lymphoma / etiology
  • Burkitt Lymphoma / genetics*
  • Burkitt Lymphoma / mortality
  • Chromosomes, Human, Pair 11
  • Cyclophosphamide
  • Doxorubicin
  • Epstein-Barr Virus Infections / drug therapy
  • Epstein-Barr Virus Infections / etiology
  • Epstein-Barr Virus Infections / genetics*
  • Epstein-Barr Virus Infections / mortality
  • Gene Expression Regulation, Neoplastic*
  • Gene Regulatory Networks
  • Heart Transplantation / adverse effects
  • Humans
  • Immunosuppression Therapy / adverse effects
  • Kidney Transplantation / adverse effects
  • Liver Transplantation / adverse effects
  • Male
  • Microtubule-Associated Proteins / genetics
  • Microtubule-Associated Proteins / metabolism
  • Middle Aged
  • Mutation
  • Prednisone
  • Proto-Oncogene Protein c-ets-1 / genetics
  • Proto-Oncogene Protein c-ets-1 / metabolism
  • Proto-Oncogene Protein c-fli-1 / genetics
  • Proto-Oncogene Protein c-fli-1 / metabolism
  • Proto-Oncogene Proteins c-myc / genetics
  • Rituximab / therapeutic use
  • Signal Transduction
  • Survival Analysis
  • Translocation, Genetic*
  • Vincristine

Substances

  • ETS1 protein, human
  • FLI1 protein, human
  • MYC protein, human
  • Microtubule-Associated Proteins
  • Proto-Oncogene Protein c-ets-1
  • Proto-Oncogene Protein c-fli-1
  • Proto-Oncogene Proteins c-myc
  • Rituximab
  • Vincristine
  • Doxorubicin
  • Cyclophosphamide
  • 1-Alkyl-2-acetylglycerophosphocholine Esterase
  • PAFAH1B2 protein, human
  • Prednisone

Supplementary concepts

  • CHOP protocol