Fabrication of magnetite-based core-shell coated nanoparticles with antibacterial properties

Biofabrication. 2015 Mar 23;7(1):015014. doi: 10.1088/1758-5090/7/1/015014.

Abstract

We report the fabrication of biofunctionalized magnetite core/sodium lauryl sulfate shell/antibiotic adsorption-shell nanoparticles assembled thin coatings by matrix assisted pulsed laser evaporation for antibacterial drug-targeted delivery. Magnetite nanoparticles have been synthesized and subsequently characterized by transmission electron microscopy and x-ray diffraction. The obtained thin coatings have been investigated by FTIR and scanning electron microscope, and tested by in vitro biological assays, for their influence on in vitro bacterial biofilm development and cytotoxicity on human epidermoid carcinoma (HEp2) cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adsorption
  • Anti-Bacterial Agents / pharmacology*
  • Biofilms / drug effects
  • Cell Line, Tumor
  • Ferric Compounds / chemistry
  • Humans
  • Lasers
  • Magnetite Nanoparticles / chemistry*
  • Magnetite Nanoparticles / ultrastructure
  • Microbial Sensitivity Tests
  • Microtechnology / methods*
  • Pseudomonas aeruginosa / drug effects
  • Pseudomonas aeruginosa / physiology
  • Sodium Dodecyl Sulfate / chemistry
  • Spectroscopy, Fourier Transform Infrared
  • Staphylococcus aureus / drug effects
  • Staphylococcus aureus / physiology
  • Volatilization
  • X-Ray Diffraction

Substances

  • Anti-Bacterial Agents
  • Ferric Compounds
  • Magnetite Nanoparticles
  • ferric oxide
  • Sodium Dodecyl Sulfate