Development of fluorescent probes specific for parallel-stranded G-quadruplexes by a library approach

Chem Commun (Camb). 2015 Apr 30;51(34):7386-9. doi: 10.1039/c5cc01601k.

Abstract

A 241-membered cyanine-based library was constructed by the combinatorial chemistry strategy. Combined with high-throughput screening, we successfully discovered a novel fluorescent probe (CyC-M716) capable of identifying a subset of parallel G-quadruplexes with propeller loops stretching across three tetrad layers with high sensitivity and selectivity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbocyanines / chemistry
  • Combinatorial Chemistry Techniques
  • Fluorescent Dyes / chemical synthesis
  • Fluorescent Dyes / chemistry*
  • G-Quadruplexes*
  • Models, Molecular
  • Small Molecule Libraries / chemical synthesis
  • Small Molecule Libraries / chemistry*

Substances

  • Carbocyanines
  • Fluorescent Dyes
  • Small Molecule Libraries
  • cyanine dye 5