Comparison of common data elements from the Managing Epilepsy Well (MEW) Network integrated database and a well-characterized sample with nonepileptic seizures

W Curt LaFrance Jr; Rebecca Ranieri; Yvan Bamps; Shelley Stoll; Satya S Sahoo; Elisabeth Welter; Johnny Sams; Curtis Tatsuoka; Martha Sajatovic

doi:10.1016/j.yebeh.2015.02.021

Comparison of common data elements from the Managing Epilepsy Well (MEW) Network integrated database and a well-characterized sample with nonepileptic seizures

Epilepsy Behav. 2015 Apr:45:136-41. doi: 10.1016/j.yebeh.2015.02.021. Epub 2015 Mar 29.

Authors

W Curt LaFrance Jr¹, Rebecca Ranieri², Yvan Bamps³, Shelley Stoll⁴, Satya S Sahoo⁵, Elisabeth Welter⁵, Johnny Sams⁵, Curtis Tatsuoka⁵, Martha Sajatovic⁵

Affiliations

¹ Rhode Island Hospital, Brown University, USA. Electronic address: william_lafrance_jr@brown.edu.
² San Paolo Hospital, Dipartimento di Scienze Della Salute Mentale, Psychiatry Branch Universita' degli Studi di Milano, Italy.
³ Rollins School of Public Health, Emory University, USA.
⁴ University of Michigan, USA.
⁵ Case Western Reserve University, USA.

PMID: 25825372
DOI: 10.1016/j.yebeh.2015.02.021

Abstract

Introduction: Epilepsy and psychogenic nonepileptic seizures (PNES) are both chronic illnesses characterized by similar and overlapping clinical features. A limited number of studies comparing people with epilepsy (PWE) and patients with PNES that address determinants of health outcomes exist. We conducted an analysis using a well-characterized sample of people with PNES and the Managing Epilepsy Well (MEW) Network integrated data, comparing descriptive data on samples with epilepsy and with documented PNES. Based on the pooled data, we hypothesized that people with PNES would have worse QOL and higher depression severity than PWE.

Material and methods: We used data from the MEW Network integrated database involving select epilepsy self-management studies comprising 182 PWE and 305 individuals with documented PNES from the Rhode Island Hospital Neuropsychiatry and Behavioral Neurology Clinic. We conducted a matched, case-control study assessing descriptive comparisons on 16 common data elements that included gender, age, ethnicity, race, education, employment, income, household composition, relationship status, age at seizure onset, frequency of seizures, seizure type, health status, healthy days, quality of life, and depression. Standardized rating scales for depression and quality of life were used.

Results: Median seizure frequency in the last 30days for PWE was 1, compared to 15 for patients with PNES (p<0.05). People with epilepsy had a QOLIE-10 mean score of 3.00 (SD: 0.91) compared to 3.54 (0.88) (p<0.01) for patients with PNES. Depression severity was moderate to severe in 7.7% of PWE compared to 34.1% (p<0.05) of patients with PNES.

Discussion: People with epilepsy in selected MEW Network programs are fairly well educated, mostly women, with few minorities and low monthly seizure rates. Those with PNES, however, have higher levels of not working/on disability and had more frequent seizures, higher depression severity, and worse QOL. These differences were present despite demographics that are largely similar in both groups, illustrating that other determinants of illness may influence PNES.

Keywords: Comorbidity; Demographics; Depression; Epilepsy; Psychogenic nonepileptic seizures; Quality of life.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Case-Control Studies
Common Data Elements
Databases, Factual
Depressive Disorder / diagnosis*
Depressive Disorder / psychology
Epilepsy / diagnosis*
Epilepsy / psychology
Female
Humans
Male
Middle Aged
Psychophysiologic Disorders / diagnosis*
Psychophysiologic Disorders / psychology
Quality of Life / psychology*
Seizures / diagnosis*
Seizures / psychology
Severity of Illness Index
Young Adult