Stroke rehabilitation and risk of mortality: a population-based cohort study stratified by age and gender

J Stroke Cerebrovasc Dis. 2015 Jun;24(6):1414-22. doi: 10.1016/j.jstrokecerebrovasdis.2015.03.006. Epub 2015 Mar 30.

Abstract

Background: To determine the survival of patients with stroke for up to 10 years after a first-time stroke and to investigate whether stroke rehabilitation within the first 3 months reduced long-term mortality in these patients.

Methods: We used the medical claims data for a random sample of 1 million insured Taiwanese registered in the year 2000. A total of 7767 patients admitted for a first-time stroke between 2000 and 2005; 1285 (16.7%) received rehabilitation within the first 3 months after stroke admission. The other 83.3% of patients served as a comparison cohort. A Cox proportional hazards model was used to estimate the relative risk of mortality in relation to the rehabilitation intervention.

Results: In all, 181 patients with rehabilitation and 1123 controls died, representing respective mortality rates of 25.0 and 32.7 per 1000 person-years. Rehabilitation was significantly associated with a lower risk of mortality (hazard ratio .68, 95% confidence interval .58-.79). Such a beneficial effect tended to be more obvious as the frequency of rehabilitation increased (P for the trend <.0001) and was more evident in female patients.

Conclusions: Stroke rehabilitation initiated in the first 3 months after a stroke admission may significantly reduce the risk of mortality for 10 years after the stroke.

Keywords: Stroke; cohort study; mortality; rehabilitation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Cohort Studies
  • Databases, Factual
  • Female
  • Humans
  • Male
  • Middle Aged
  • Risk Factors
  • Sex Factors
  • Stroke / mortality*
  • Stroke Rehabilitation*
  • Taiwan / epidemiology