Evaluation of influenza vaccine effectiveness and description of circulating strains in outpatient settings in South Africa, 2014

Influenza Other Respir Viruses. 2015 Jul;9(4):209-15. doi: 10.1111/irv.12314.

Abstract

The effectiveness of the trivalent seasonal influenza vaccine during the 2014 season in South Africa was assessed using a test-negative case-control study design including 472 cases and 362 controls. Influenza A(H3N2) was the dominant strain circulating. The overall vaccine effectiveness estimate, adjusted for age and underlying conditions, was 43·1% (95% CI: -26·8-74·5). 2014 H3N2 viruses from South Africa were mainly in sublineage 3C.3 with accumulation of amino acid changes that differentiate them from the vaccine strain in 3C.1.

Keywords: Effectiveness; influenza; vaccine.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Case-Control Studies
  • Female
  • Humans
  • Influenza Vaccines / administration & dosage*
  • Influenza Vaccines / immunology
  • Influenza, Human / epidemiology*
  • Influenza, Human / immunology
  • Influenza, Human / prevention & control*
  • Influenza, Human / virology
  • Male
  • Middle Aged
  • Outpatients
  • Seasons
  • Sentinel Surveillance
  • South Africa / epidemiology
  • Young Adult

Substances

  • Influenza Vaccines