Controlling epileptiform activity with organic electronic ion pumps

Adv Mater. 2015 May 27;27(20):3138-44. doi: 10.1002/adma.201500482. Epub 2015 Apr 11.

Abstract

In treating epilepsy, the ideal solution is to act at a seizure's onset, but only in the affected regions of the brain. Here, an organic electronic ion pump is demonstrated, which directly delivers on-demand pure molecules to specific brain regions. State-of-the-art organic devices and classical pharmacology are combined to control pathological activity in vitro, and the results are verified with electrophysiological recordings.

Keywords: PEDOT:PSS; neuroengineering; organic bioelectronics; organic electronic ion pumps.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Action Potentials / drug effects
  • Action Potentials / physiology
  • Animals
  • Anticonvulsants / administration & dosage
  • CA1 Region, Hippocampal / drug effects
  • CA1 Region, Hippocampal / physiopathology*
  • CA3 Region, Hippocampal / drug effects
  • CA3 Region, Hippocampal / physiopathology*
  • Chlorates / metabolism
  • Electrical Equipment and Supplies*
  • Electrons
  • Epilepsy / physiopathology*
  • Epilepsy / therapy*
  • Equipment Design
  • Ions / administration & dosage
  • Magnesium / metabolism
  • Mice
  • Pyramidal Cells / drug effects
  • Pyramidal Cells / physiology
  • Tissue Culture Techniques
  • gamma-Aminobutyric Acid / administration & dosage

Substances

  • Anticonvulsants
  • Chlorates
  • Ions
  • gamma-Aminobutyric Acid
  • Magnesium
  • chloric acid