Something in the air: hyperoxic conditioning of the tumor microenvironment for enhanced immunotherapy

Robert D Leone; Maureen R Horton; Jonathan D Powell

doi:10.1016/j.ccell.2015.03.014

Something in the air: hyperoxic conditioning of the tumor microenvironment for enhanced immunotherapy

Cancer Cell. 2015 Apr 13;27(4):435-6. doi: 10.1016/j.ccell.2015.03.014.

Authors

Robert D Leone¹, Maureen R Horton², Jonathan D Powell³

Affiliations

¹ Sidney Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
² Pulmonary Division, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
³ Sidney Kimmel Comprehensive Cancer Research Center, Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address: poweljo@jhmi.edu.

Abstract

Recent clinical trials in cancer therapy have demonstrated unprecedented responses through blockade of CTLA-4 and PD-1 immune checkpoint pathways. In a provocative recent paper in Science Translational Medicine, Hatfield and colleagues demonstrate the ability of supplemental oxygen to act as a novel immune checkpoint inhibitor by disrupting the hypoxia-adenosine-A2aR pathway.

Publication types

Comment

MeSH terms

Animals
Antineoplastic Agents / therapeutic use*
Female
Humans
Neoplasms / drug therapy*
Neoplasms / immunology*
Oxygen / therapeutic use*

Substances

Antineoplastic Agents
Oxygen

Grants and funding

P30 CA006973/CA/NCI NIH HHS/United States