Analysis of functional variants reveals new candidate genes associated with alexithymia

Psychiatry Res. 2015 Jun 30;227(2-3):363-5. doi: 10.1016/j.psychres.2015.03.018. Epub 2015 Mar 27.

Abstract

In this study we explored the possible association between 36,915 functional variants and alexithymia, a personality trait characterized by the inability to identify and describe emotions and feelings. From our analysis, variants in the genes ABCB4, TP53AIP1, ARHGAP32 and TMEM88B were identified linked to the alexithymia phenotype.

Keywords: ABCB4; Alexithymia; Functional variants.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B / genetics*
  • Adolescent
  • Adult
  • Affective Symptoms / diagnosis
  • Affective Symptoms / genetics*
  • Affective Symptoms / psychology
  • Aged
  • Case-Control Studies
  • DNA-Binding Proteins / genetics*
  • Emotions*
  • Female
  • Humans
  • Male
  • Membrane Proteins / genetics*
  • Middle Aged
  • Personality Inventory
  • Phenotype
  • Tumor Suppressor Proteins / genetics*
  • Young Adult

Substances

  • ATP Binding Cassette Transporter, Subfamily B
  • DNA-Binding Proteins
  • Membrane Proteins
  • TMEM8B protein, human
  • TP53TG1 protein, human
  • Tumor Suppressor Proteins
  • multidrug resistance protein 3