Premenstrual syndrome, the recurrent luteal phase deterioration in quality of life due to disruptive physical and psychiatric symptomatology, is a distinct clinical condition caused by an abnormal central nervous system response to the hormonal changes of the female reproductive cycle. Better definition and research based on strict inclusion/ exclusion criteria have allowed the development of successful treatments that are tailored to the severity of the lifestyle disruption and the specific individual constellation of symptoms. Charting and simple lifestyle changes may improve coping skills for many women. However, more severely affected individuals often require medical interventions to augment central serotonin/ norepinephrine levels or to suppress the hormonal changes of the menstrual cycle. For extended coverage of this and related topics, please see our FREE on-line web- text www.endotext.org.
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