Association between new onset diabetic retinopathy and monocyte chemoattractant protein-1 (MCP-1) polymorphism in Japanese type 2 diabetes

Hiroyo Ninomiya; Naoto Katakami; Takeshi Osonoi; Miyoko Saitou; Yuichi Yamamoto; Mitsuyoshi Takahara; Dan Kawamori; Taka-aki Matsuoka; Yoshimitsu Yamasaki; Iichiro Shimomura

doi:10.1016/j.diabres.2015.04.006

Association between new onset diabetic retinopathy and monocyte chemoattractant protein-1 (MCP-1) polymorphism in Japanese type 2 diabetes

Diabetes Res Clin Pract. 2015 Jun;108(3):e35-7. doi: 10.1016/j.diabres.2015.04.006. Epub 2015 Apr 13.

Affiliations

¹ Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.
² Department of Metabolic Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan; Department of Metabolism and Atherosclerosis, Osaka University Graduate School of Medicine, Suita, Osaka, Japan. Electronic address: katakami@endmet.med.osaka-u.ac.jp.
³ Naka Memorial Clinic, Naka, Ibaraki, Japan.

PMID: 25913234
DOI: 10.1016/j.diabres.2015.04.006

Abstract

We longitudinally evaluated the association between monocyte chemoattractant protein-1 (MCP-1) A-2518G polymorphism and new onset of diabetic retinopathy in 758 type 2 diabetic patients. The new onset of retinopathy increased with the increase of the number of G alleles, even after adjustment for age, HbA1c levels, and duration of diabetes.

Keywords: MCP-1; Retinopathy; SNP.

MeSH terms

Aged
Asian People / genetics
Asian People / statistics & numerical data
Chemokine CCL2 / genetics*
Cohort Studies
Diabetes Mellitus, Type 2 / complications*
Diabetic Retinopathy / genetics*
Female
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Japan / epidemiology
Longitudinal Studies
Male
Middle Aged
Polymorphism, Single Nucleotide

Substances

CCL2 protein, human
Chemokine CCL2