EBV-associated lymphoepithelioma-like carcinoma of the pancreas: Case report with targeted sequencing analysis

Pancreatology. 2015 May-Jun;15(3):302-4. doi: 10.1016/j.pan.2015.03.016. Epub 2015 Apr 9.

Abstract

Lymphoepithelioma-like carcinomas are distinctive epithelial derived malignant neoplasms that have a syncytial growth pattern and lymphoid stroma. The majority of tumors with this appearance are Epstein Barr virus (EBV)-associated. We report a patient with a clinical presentation concerning for lymphoma who was diagnosed with an EBV-associated pancreatic carcinoma with a lymphoepithelioma-like pattern. Targeted sequencing analysis showed a molecular profile distinct from conventional ductal adenocarcinoma of the pancreas.

Keywords: EBV-associated carcinoma; Epstein Barr virus; Lymphoepithelial-like carcinoma; Lymphoepithelioma-like carcinoma; Pancreas carcinoma; Targeted molecular analysis.

Publication types

  • Case Reports

MeSH terms

  • Biomarkers, Tumor / genetics*
  • Carcinoma / diagnosis
  • Carcinoma / genetics
  • Carcinoma / virology*
  • DNA Mutational Analysis
  • Herpesvirus 4, Human / isolation & purification*
  • Humans
  • Male
  • Middle Aged
  • Mutation
  • Pancreatic Neoplasms / diagnosis
  • Pancreatic Neoplasms / genetics
  • Pancreatic Neoplasms / virology*

Substances

  • Biomarkers, Tumor