Prevalence of HLA-B*57:01 allele in Argentinean HIV-1 infected patients

Tissue Antigens. 2015 Jul;86(1):28-31. doi: 10.1111/tan.12575. Epub 2015 Apr 29.

Abstract

Hypersensitivity reaction to abacavir (ABC hypersensitivity syndrome, AHS) is strongly associated with the presence of the HLA-B*57:01 allele. This study was designed to estimate the prevalence of HLA-B*57:01 allele in Argentinean HIV-1 infected patients. We analyzed the presence of HLA-B*57:01 allele in 1646 HIV-1 infected patients from different regions of Argentina. This allele was detected in 81 patients; most of them corresponded to patients living in the central region of the country. The prevalence of HLA-B*57:01 was 4.9%, similar to other Caucasian populations and higher than other data reported for South American populations. This strongly supports screening for the presence of HLA-B*57:01 in abacavir treatment of HIV-1 in our country.

Keywords: HIV-1; HLA-B*57:01 genotyping; abacavir; frequency; hypersensitivity; pharmacogenetics.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles
  • Anti-HIV Agents / administration & dosage
  • Anti-HIV Agents / adverse effects*
  • Argentina
  • Dideoxynucleosides / administration & dosage
  • Dideoxynucleosides / adverse effects*
  • Drug Hypersensitivity / diagnosis*
  • Drug Hypersensitivity / etiology
  • Drug Hypersensitivity / genetics*
  • Drug Hypersensitivity / immunology
  • Female
  • Gene Expression
  • Gene Frequency
  • Genetic Testing
  • HIV Infections / drug therapy
  • HIV Infections / genetics*
  • HIV Infections / immunology
  • HIV Infections / virology
  • HIV-1 / immunology
  • HLA-B Antigens / genetics*
  • HLA-B Antigens / immunology
  • Humans
  • Male
  • Middle Aged

Substances

  • Anti-HIV Agents
  • Dideoxynucleosides
  • HLA-B Antigens
  • HLA-B*57:01 antigen
  • abacavir