A-62-years-old man was admitted our hospital because of angina at rest and during effort. Coronary angiography revealed 25% fixed stenosis in Seg. 6, 90% in Seg. 7, 75% in Seg. 10, and 50% in Seg. 12. Percutaneous transluminal angioplasty was performed for segment 7 and complete revascularization was obtained finally. Two and a half months later, progressive lesion occurred in the segment proximal to the angioplasty site (Seg. 6). The manipulation of the guiding catheter in the coronary artery proximal to the PTCA site might have developed atherogenesis in this area. So we must consider the possibilities of both restenosis and new lesions when one has the recurrence of ischemic symptoms after coronary angioplasty.