Historical Outbreaks of Simian Hemorrhagic Fever in Captive Macaques Were Caused by Distinct Arteriviruses

Michael Lauck; Sergey V Alkhovsky; Yīmíng Bào; Adam L Bailey; Zinaida V Shevtsova; Alexey M Shchetinin; Tatyana V Vishnevskaya; Matthew G Lackemeyer; Elena Postnikova; Steven Mazur; Jiro Wada; Sheli R Radoshitzky; Thomas C Friedrich; Boris A Lapin; Petr G Deriabin; Peter B Jahrling; Tony L Goldberg; David H O'Connor; Jens H Kuhn

doi:10.1128/JVI.01046-15

Historical Outbreaks of Simian Hemorrhagic Fever in Captive Macaques Were Caused by Distinct Arteriviruses

J Virol. 2015 Aug;89(15):8082-7. doi: 10.1128/JVI.01046-15. Epub 2015 May 13.

Authors

Michael Lauck¹, Sergey V Alkhovsky², Yīmíng Bào³, Adam L Bailey¹, Zinaida V Shevtsova⁴, Alexey M Shchetinin², Tatyana V Vishnevskaya², Matthew G Lackemeyer⁵, Elena Postnikova⁵, Steven Mazur⁵, Jiro Wada⁵, Sheli R Radoshitzky⁶, Thomas C Friedrich¹, Boris A Lapin⁷, Petr G Deriabin², Peter B Jahrling⁵, Tony L Goldberg¹, David H O'Connor¹, Jens H Kuhn⁸

Affiliations

¹ University of Wisconsin-Madison, Madison, Wisconsin, USA.
² D. I. Ivanovsky Institute of Virology, N. F. Gamaleya Federal Research Center for Epidemiology and Microbiology, Ministry of Health of the Russian Federation, Moscow, Russia.
³ Information Engineering Branch, National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland, USA.
⁴ Scientific-Research Institute of Experimental Pathology and Therapy, Abkhazian Academy of Sciences, Sukhumi, Georgia.
⁵ Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, Maryland, USA.
⁶ United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA.
⁷ Scientific-Research Institute of Medical Primatology, Russian Academy of Medical Sciences, Sochi, Russia.
⁸ Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, Maryland, USA kuhnjens@mail.nih.gov.

Abstract

Simian hemorrhagic fever (SHF) is lethal for macaques. Based on clinical presentation and serological diagnosis, all reported SHF outbreaks were thought to be caused by different strains of the same virus, simian hemorrhagic fever virus (SHFV; Arteriviridae). Here we show that the SHF outbreaks in Sukhumi in 1964 and in Alamogordo in 1989 were caused not by SHFV but by two novel divergent arteriviruses. Our results indicate that multiple divergent simian arteriviruses can cause SHF.

Publication types

Historical Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural

MeSH terms

Amino Acid Sequence
Animals
Arterivirus / classification
Arterivirus / genetics
Arterivirus / isolation & purification*
Arterivirus / physiology
Arterivirus Infections / history
Arterivirus Infections / veterinary*
Arterivirus Infections / virology
Evolution, Molecular
Hemorrhagic Fevers, Viral / history
Hemorrhagic Fevers, Viral / veterinary*
Hemorrhagic Fevers, Viral / virology
History, 20th Century
Humans
Macaca / virology*
Molecular Sequence Data
Phylogeny
Primate Diseases / history
Primate Diseases / virology*
Sequence Homology, Amino Acid
Viral Proteins / chemistry
Viral Proteins / genetics

Historical Outbreaks of Simian Hemorrhagic Fever in Captive Macaques Were Caused by Distinct Arteriviruses

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