A common assembly module in injectisome and flagellar type III secretion sorting platforms

Nat Commun. 2015 May 21:6:7125. doi: 10.1038/ncomms8125.

Abstract

Translocating proteins across the double membrane of Gram-negative bacteria, type III secretion systems (T3SS) occur in two evolutionarily related forms: injectisomes, delivering virulence factors into host cells, and the flagellar system, secreting the polymeric filament used for motility. While both systems share related elements of a cytoplasmic sorting platform that facilitates the hierarchical secretion of protein substrates, its assembly and regulation remain unclear. Here we describe a module mediating the assembly of the sorting platform in both secretion systems, and elucidate the structural basis for segregation of homologous components among these divergent T3SS subtypes sharing a common cytoplasmic milieu. These results provide a foundation for the subtype-specific assembly of T3SS sorting platforms and will support further mechanistic analysis and anti-virulence drug design.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Flagella / metabolism
  • Magnetic Resonance Spectroscopy
  • Molecular Sequence Data
  • Protein Structure, Tertiary
  • Salmonella typhimurium
  • Type III Secretion Systems / chemistry*
  • Type III Secretion Systems / genetics
  • Type III Secretion Systems / metabolism

Substances

  • Type III Secretion Systems

Associated data

  • PDB/4YX1
  • PDB/4YX5
  • PDB/4YX7
  • PDB/4YXA
  • PDB/4YXB
  • PDB/4YXC