Store-operated calcium entry: Mechanisms and modulation

Biochem Biophys Res Commun. 2015 Apr 24;460(1):40-9. doi: 10.1016/j.bbrc.2015.02.110.

Abstract

Store-operated calcium entry is a central mechanism in cellular calcium signalling and in maintaining cellular calcium balance. This review traces the history of research on store-operated calcium entry, the discovery of STIM and ORAI as central players in calcium entry, and the role of STIM and ORAI in biology and human disease. It describes current knowledge of the basic mechanism of STIM-ORAI signalling and of the varied mechanisms by which STIM-ORAI signalling can be modulated.

Keywords: CRAC current; Calcium channel; ORAI1; STIM1; Store-operated calcium entry.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Calcium / metabolism*
  • Calcium Channels / metabolism*
  • Calcium Signaling / physiology*
  • Cell Membrane / physiology*
  • Humans
  • Ion Channel Gating / physiology*
  • Membrane Proteins / metabolism*
  • Models, Biological*
  • ORAI1 Protein

Substances

  • Calcium Channels
  • Membrane Proteins
  • ORAI1 Protein
  • ORAI1 protein, human
  • Calcium