The promyelocytic leukemia protein is upregulated in conditions of obesity and liver steatosis

Arkaitz Carracedo; Déborah Rousseau; Nicholas Douris; Sonia Fernández-Ruiz; Natalia Martín-Martín; Dror Weiss; Kaitlyn Webster; Andrew C Adams; Mercedes Vazquez-Chantada; Maria L Martinez-Chantar; Rodolphe Anty; Albert Tran; Eleftheria Maratos-Flier; Philippe Gual; Pier Paolo Pandolfi

doi:10.7150/ijbs.11615

The promyelocytic leukemia protein is upregulated in conditions of obesity and liver steatosis

Int J Biol Sci. 2015 Apr 11;11(6):629-32. doi: 10.7150/ijbs.11615. eCollection 2015.

Authors

Affiliations

¹ 1. Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA ; 2. CIC bioGUNE, Bizkaia Technology Park, Derio, Spain ; 3. IKERBASQUE, Basque foundation for science, Bilbao, Spain ; 4. Biochemistry and Molecular Biology Department, University of the Basque Country (UPV/EHU), P. O. Box 644, E-48080 Bilbao, Spain.
² 5. INSERM, U1065, Team 8, "Hepatic Complications in Obesity", Nice, F-06204, Cedex 3, France ; 6. University of Nice-Sophia-Antipolis, Faculty of Medecine, Nice, F-06107, Cedex 2, France.
³ 7. Division of Endocrinology; Department of Medicine,Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA 02215, USA.
⁴ 2. CIC bioGUNE, Bizkaia Technology Park, Derio, Spain.
⁵ 1. Cancer Research Institute, Beth Israel Deaconess Cancer Center, Department of Medicine and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
⁶ 7. Division of Endocrinology; Department of Medicine,Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA 02215, USA ; 8. Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, USA.
⁷ 2. CIC bioGUNE, Bizkaia Technology Park, Derio, Spain ; 9. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd).
⁸ 5. INSERM, U1065, Team 8, "Hepatic Complications in Obesity", Nice, F-06204, Cedex 3, France ; 6. University of Nice-Sophia-Antipolis, Faculty of Medecine, Nice, F-06107, Cedex 2, France ; 10. CHU of Nice, Digestive Center, Nice, F-06202, Cedex 3, France.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Animals
Fatty Liver / genetics*
Fatty Liver / metabolism
Female
Humans
Liver / metabolism
Male
Mice
Nuclear Proteins / genetics*
Nuclear Proteins / metabolism
Obesity / genetics*
Obesity / metabolism
Promyelocytic Leukemia Protein
RNA, Messenger / metabolism
Transcription Factors / genetics*
Transcription Factors / metabolism
Tumor Suppressor Proteins / genetics*
Tumor Suppressor Proteins / metabolism
Up-Regulation*

Substances

Nuclear Proteins
Promyelocytic Leukemia Protein
RNA, Messenger
Transcription Factors
Tumor Suppressor Proteins
PML protein, human

Publication types

MeSH terms

Substances

Grants and funding