The influence of Sr content in calcium phosphate coatings

Mater Sci Eng C Mater Biol Appl. 2015 Aug:53:322-30. doi: 10.1016/j.msec.2015.04.015. Epub 2015 Apr 14.

Abstract

In this study calcium phosphate coatings with different amounts of strontium (Sr) were prepared using a biomineralization method. The incorporation of Sr changed the composition and morphology of coatings from plate-like to sphere-like morphology. Dissolution testing indicated that the solubility of the coatings increased with increased Sr concentration. Evaluation of extracts (with Sr concentrations ranging from 0 to 2.37 μg/mL) from the HA, 0.06Sr, 0.6Sr, and 1.2Sr coatings during in vitro cell cultures showed that Sr incorporation into coatings significantly enhanced the ALP activity in comparison to cells treated with control and HA eluted media. These findings show that calcium phosphate coatings could promote osteogenic differentiation even in a low amount of strontium.

Keywords: Calcium phosphate coatings; In vitro study; Ion release; Strontium.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Calcium Phosphates / chemistry*
  • Calcium Phosphates / pharmacology*
  • Cell Differentiation / drug effects
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Coated Materials, Biocompatible / chemistry*
  • Coated Materials, Biocompatible / pharmacology*
  • Humans
  • Materials Testing
  • Solubility
  • Strontium / chemistry*
  • Strontium / pharmacology*
  • Surface Properties

Substances

  • Calcium Phosphates
  • Coated Materials, Biocompatible
  • calcium phosphate
  • Strontium