Multicomponent dipeptide hydrogels as extracellular matrix-mimetic scaffolds for cell culture applications

Chem Commun (Camb). 2015 Jun 30;51(56):11260-3. doi: 10.1039/c5cc03162a.

Abstract

Fmoc-3F-Phe-Arg-NH2 and Fmoc-3F-Phe-Asp-OH dipeptides undergo coassembly to form two-component nanofibril hydrogels. These hydrogels support the viability and growth of NIH 3T3 fibroblast cells. The supramolecular display of Arg and Asp at the nanofibril surface effectively mimics the integrin-binding RGD peptide of fibronectin, without covalent connection between the Arg and Asp functionality.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Biomimetic Materials / chemistry*
  • Biomimetics
  • Cell Culture Techniques / methods*
  • Cell Survival
  • Dipeptides / chemistry*
  • Extracellular Matrix / chemistry*
  • Fibroblasts / cytology*
  • Hydrogels / chemistry*
  • Mice
  • Models, Molecular
  • Molecular Conformation
  • NIH 3T3 Cells
  • Nanofibers / chemistry

Substances

  • Dipeptides
  • Hydrogels