Cardiac toxoplasmosis after heart transplantation diagnosed by endomyocardial biopsy

Transpl Infect Dis. 2015 Oct;17(5):719-22. doi: 10.1111/tid.12415. Epub 2015 Jul 16.

Abstract

We describe a case of cardiac toxoplasmosis diagnosed by routine endomyocardial biopsy in a patient with trimethoprim-sulfamethoxazole (TMP-SMX) intolerance on atovaquone prophylaxis. Data are not available on the efficacy of atovaquone as Toxoplasma gondii prophylaxis after heart transplantation. In heart transplant patients in whom TMP-SMX is not an option, other strategies may be considered, including the addition of pyrimethamine to atovaquone.

Keywords: Toxoplasma gondii; diagnosis; endomyocardial biopsy; heart transplantation; prophylaxis; toxoplasmosis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anti-Infective Agents / therapeutic use
  • Atovaquone / therapeutic use
  • Biopsy
  • Heart Transplantation*
  • Humans
  • Male
  • Myocardium / pathology*
  • Postoperative Complications / pathology*
  • Postoperative Complications / prevention & control
  • Toxoplasmosis / etiology
  • Toxoplasmosis / pathology*
  • Toxoplasmosis / prevention & control

Substances

  • Anti-Infective Agents
  • Atovaquone