The Swedish CArdioPulmonary BioImage Study: objectives and design

G Bergström; G Berglund; A Blomberg; J Brandberg; G Engström; J Engvall; M Eriksson; U de Faire; A Flinck; M G Hansson; B Hedblad; O Hjelmgren; C Janson; T Jernberg; Å Johnsson; L Johansson; L Lind; C-G Löfdahl; O Melander; C J Östgren; A Persson; M Persson; A Sandström; C Schmidt; S Söderberg; J Sundström; K Toren; A Waldenström; H Wedel; J Vikgren; B Fagerberg; A Rosengren

doi:10.1111/joim.12384

The Swedish CArdioPulmonary BioImage Study: objectives and design

J Intern Med. 2015 Dec;278(6):645-59. doi: 10.1111/joim.12384. Epub 2015 Jun 19.

Authors

G Bergström^{1

2}, G Berglund³, A Blomberg⁴, J Brandberg^{5

6}, G Engström³, J Engvall^{7

8

9}, M Eriksson¹⁰, U de Faire^{11

12}, A Flinck^{5

6}, M G Hansson¹³, B Hedblad³, O Hjelmgren^{1

2}, C Janson¹⁴, T Jernberg^{12

15}, Å Johnsson^{5

6}, L Johansson¹⁶, L Lind¹⁷, C-G Löfdahl^{3

18}, O Melander^{3

19}, C J Östgren⁸, A Persson^{9

20}, M Persson^{3

19}, A Sandström²¹, C Schmidt¹, S Söderberg²¹, J Sundström^{17

22}, K Toren²³, A Waldenström²⁴, H Wedel²⁵, J Vikgren^{5

6}, B Fagerberg¹, A Rosengren¹

Affiliations

¹ Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden.
² Department of Clinical Physiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
³ Department of Clinical Sciences, Lund University, Lund, Sweden.
⁴ Department of Public Health and Clinical Medicine, Division of Medicine/Respiratory Medicine, Umeå University, Umeå, Sweden.
⁵ Department of Radiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
⁶ Department of Radiology, University of Gothenburg, Gothenburg, Sweden.
⁷ Department of Clinical Physiology, County Council of Östergötland, Linköping, Sweden.
⁸ Department of Medical and Health Sciences, Linköping University, Linköping, Sweden.
⁹ Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden.
¹⁰ Department of Endocrinology, Metabolism and Diabetes, Karolinska University Hospital, Stockholm, Sweden.
¹¹ Unit of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
¹² Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden.
¹³ Department of Public Health and Caring Sciences, Centre for Research Ethics and Bioethics, Uppsala University, Uppsala, Sweden.
¹⁴ Department of Medical Sciences: Respiratory, Allergy and Sleep Research, Uppsala University, Uppsala, Sweden.
¹⁵ Department of Medicine, Karolinska Institutet, Huddinge, Sweden.
¹⁶ Department of Radiology, Oncology and Radiation Science, Unit of Radiology, Uppsala, Sweden.
¹⁷ Department of Clinical Sciences, Uppsala University, Uppsala, Sweden.
¹⁸ Department of Respiratory Medicine and Allergology, Lund University Hospital, Lund, Sweden.
¹⁹ Department of Internal Medicine, Skåne University Hospital, Malmö, Sweden.
²⁰ Department of Radiology in Linkoping, County Council of Östergötland, Linköping, Sweden.
²¹ Department of Public Health and Clinical Medicine, Medicine and Heart Centre, Umeå University, Umeå, Sweden.
²² Uppsala Clinical Research Centre, Uppsala, Sweden.
²³ Section of Occupational and Environmental Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
²⁴ Department of Public Health and Clinical Medicine Thoracic Center, Umeå University Hospital, Umeå University, Umeå, Sweden.
²⁵ Epidemiology and Biostatistics, Nordic School of Public Health, Gothenburg, Sweden.

Abstract

Cardiopulmonary diseases are major causes of death worldwide, but currently recommended strategies for diagnosis and prevention may be outdated because of recent changes in risk factor patterns. The Swedish CArdioPulmonarybioImage Study (SCAPIS) combines the use of new imaging technologies, advances in large-scale 'omics' and epidemiological analyses to extensively characterize a Swedish cohort of 30 000 men and women aged between 50 and 64 years. The information obtained will be used to improve risk prediction of cardiopulmonary diseases and optimize the ability to study disease mechanisms. A comprehensive pilot study in 1111 individuals, which was completed in 2012, demonstrated the feasibility and financial and ethical consequences of SCAPIS. Recruitment to the national, multicentre study has recently started.

Keywords: cardiovascular; epidemiology; metabolism; pulmonary; trial design.

Publication types

Observational Study
Research Support, Non-U.S. Gov't

MeSH terms

Cardiovascular Diseases* / diagnosis
Cardiovascular Diseases* / epidemiology
Cardiovascular Diseases* / etiology
Cardiovascular Diseases* / metabolism
Cardiovascular Diseases* / therapy
Female
Genetic Techniques
Humans
Male
Middle Aged
Prospective Studies
Proteomics / methods
Public Health / methods
Public Health / statistics & numerical data
Pulmonary Disease, Chronic Obstructive* / diagnosis
Pulmonary Disease, Chronic Obstructive* / epidemiology
Pulmonary Disease, Chronic Obstructive* / etiology
Pulmonary Disease, Chronic Obstructive* / metabolism
Pulmonary Disease, Chronic Obstructive* / therapy
Risk Factors
Socioeconomic Factors
Sweden / epidemiology