Structure of a protected C(1)-C(10) subunit of erythronolides A and B

Acta Crystallogr C. 1989 Jun 15:45 ( Pt 6):973-5. doi: 10.1107/s0108270188013666.

Abstract

C19H34O4, Mr = 326.48, orthorhombic, P2(1)2(1)2(1), a = 7.949 (2), b = 14.880 (5), c = 17.047 (5) A, V = 2016 (1) A3, Z = 4, Dx = 1.08 g cm-3, mu = 0.6861 cm-1, lambda(Mo K alpha) = 0.71069 A, F(000) = 720, T = 163 K, R = 0.0644 for 1476 reflections [Fo greater than or equal to 4 sigma (Fo)]. There is an intermolecular H bond involving the hydroxyl group and the carbonyl O (related by 1/2 + x, 3/2 - y, 1 - z) with an O...O distance of 2.838 (5) A, an H...O distance of 2.06 (5) A and an O-H...O angle of 172 (6) degrees. There are no such intramolecular contacts.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Crystallography
  • Erythromycin / analogs & derivatives*
  • Molecular Structure

Substances

  • erythronolide A
  • erythronolide B
  • Erythromycin