Gliomas with intratumoral abscess formation: Description of new cases, review of the literature, and the role of (99m)TC-Leukoscan

Kaohsiung J Med Sci. 2015 Jul;31(7):377-83. doi: 10.1016/j.kjms.2015.03.003. Epub 2015 May 30.

Abstract

Abscess formation within a brain tumor is uncommon. Intrasellar or parasellar tumors are the most common neoplasms that develop such complications. Cerebral gliomas with abscesses are extremely rare. In this paper three rare cases of glioma associated with abscess formation are described. The diagnosis of brain tumor associated with abscess is particularly difficult by conventional neuroradiological studies. (99m)Tc-labeled sulesomab can be useful in the diagnosis of brain tumors with intratumoral abscesses. There are no precise guidelines for the diagnosis and treatment of cerebral gliomas associated with abscesses formation for the low number of cases reported to date. Appropriate treatment, aimed at radical surgery, and a suitable antibiotic-protocol, deferring adjuvant postoperative therapy, is associated with a more favorable outcome. A review of the pertinent literature is also performed.

Keywords: Brain abscess; Cerebral gliomas; Intratumoral abscess; Leukoscan; Sulesomab.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Antibodies, Monoclonal, Murine-Derived / therapeutic use*
  • Brain Abscess / drug therapy*
  • Brain Abscess / pathology
  • Brain Neoplasms / drug therapy*
  • Brain Neoplasms / pathology
  • Fatal Outcome
  • Female
  • Glioma / drug therapy*
  • Glioma / pathology
  • Humans
  • Magnetic Resonance Imaging
  • Middle Aged
  • Tomography

Substances

  • Antibodies, Monoclonal, Murine-Derived
  • Sulesomab