[Dermatological manifestations of monoclonal gammopathies: contribution of cutaneous histopathology]

Abstract

Skin manifestations associated with monoclonal gammapathy are common and can present with various clinical and pathological aspects. They can be the first events leading to the diagnosis of monoclonal gammapathy. They may be present either as specific lesions, including lymphoplasmacytic or pure plasma cell neoplastic infiltrates and monoclonal immunoglobulin deposits, or as non-specific dermatitis, such as leukocytoclastic vasculitis, neutrophilic dermatoses, mucinoses or xanthomatosis, giving little clues for the diagnosis of the underlying disease.

Keywords: Gammapathie monoclonale; Histopathologie cutanée; Hémopathie lymphoplasmocytaire et plasmocytaire; Monoclonal gammapathy; Plasmocytic and lymphoplasmocytic hemopathy; Skin histopathology.