Bioactive cembranoids from the South China Sea soft coral Sarcophyton elegans

Molecules. 2015 Jul 22;20(7):13324-35. doi: 10.3390/molecules200713324.

Abstract

Four new cembranoids, sarcophelegans A-D (1-4) and six known analogues (5-10) were isolated from the South China Sea soft coral Sarcophyton elegans. Their structures were elucidated through detailed spectroscopic analysis, and the absolute configuration of 1 was confirmed by single-crystal X-ray diffraction. The antimigratory potential of compounds 1-10 were evaluated and compounds 2 and 6 were found to inhibit human breast tumor MDA-MB-231 cell migration at 10 μM.

Keywords: Sarcophyton elegans; antimigratory activity; cembranoids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Cell Line, Tumor
  • Cell Movement / drug effects*
  • Diterpenes* / chemistry
  • Diterpenes* / isolation & purification
  • Diterpenes* / pharmacology
  • Female
  • Humans

Substances

  • Diterpenes