Multifunctional Thrombin-Activatable Polymer Capsules for Specific Targeting to Activated Platelets

Adv Mater. 2015 Sep 16;27(35):5153-7. doi: 10.1002/adma.201502243. Epub 2015 Aug 3.

Abstract

Smart poly(2-oxazoline) (POx)-based multifunctional polymer capsules that specifically target glycoprotein (GP) IIb/IIIa on the surface of activated platelets are degraded by the serine protease thrombin and release the urokinase plasminogen activator loaded into the polymer capsules, only in the area of acute thrombosis.

Keywords: antibodies; drug delivery; plasminogen activators; polymer carriers; thrombosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Blood Platelets / drug effects*
  • Blood Platelets / physiology*
  • Capsules
  • Drug Carriers / chemistry*
  • Humans
  • Oligopeptides / chemistry
  • Oxazoles / chemistry*
  • Platelet Activation / drug effects*
  • Thrombin / metabolism*
  • Thrombosis / physiopathology
  • Urokinase-Type Plasminogen Activator / chemistry
  • Urokinase-Type Plasminogen Activator / metabolism
  • Urokinase-Type Plasminogen Activator / pharmacology

Substances

  • Capsules
  • Drug Carriers
  • Oligopeptides
  • Oxazoles
  • poly(2-oxazoline)
  • arginyl-glycyl-aspartic acid
  • Thrombin
  • Urokinase-Type Plasminogen Activator