NETs and traps delay wound healing in diabetes

Trends Endocrinol Metab. 2015 Sep;26(9):451-2. doi: 10.1016/j.tem.2015.07.004. Epub 2015 Jul 31.

Abstract

Diabetes is associated with dire peripheral sequelae including foot ulcers and amputations. A recent article by Wong et al. demystifies this connection by demonstrating that the neutrophil defense mechanism of extruding decondensed chromatin, termed NETosis, mediates delayed wound healing in diabetes and provides a therapeutic strategy for this indication.

Publication types

  • Review

MeSH terms

  • Citrulline / metabolism
  • Diabetes Complications / pathology*
  • Extracellular Traps* / drug effects
  • Humans
  • Hydrolases / genetics
  • Hydrolases / metabolism
  • Protein-Arginine Deiminase Type 4
  • Protein-Arginine Deiminases
  • Wound Healing* / drug effects

Substances

  • Citrulline
  • Hydrolases
  • PADI4 protein, human
  • Protein-Arginine Deiminase Type 4
  • Protein-Arginine Deiminases