Does hepatic hilum morphology influence long-term prognosis in type I/I cyst biliary atresia?

Pediatr Surg Int. 2015 Oct;31(10):931-6. doi: 10.1007/s00383-015-3771-3. Epub 2015 Aug 14.

Abstract

Purpose: Some patients with cystic biliary atresia (BA) achieve exceptionally good postoperative courses. Early differentiation of pediatric patients with the favorable-type disease can lead to beneficial long-term postoperative management. We examined whether the hepatic hilum morphology affects long-term prognosis in type I/I cyst BA, atresia of the common bile duct with/without a cyst.

Methods: Of 253 BA patients identified since 1972, 40 were classified as having type I/I cysts and were divided into two subtypes according to hepatic duct size (subtype α: n = 18; duct diameter, ≥ 1 mm and subtype β: n = 22; duct diameter, <1 mm) to compare postoperative clinical courses.

Results: In subtypes α and β, jaundice disappeared in 16 (89 %) and 19 (86 %) patients, respectively (p = 0.81), and 13 (72 %) and 12 (55 %) survived with native livers (p = 0.18) at a mean age of 23.3 and 25.5 years, respectively (p = 0.42).

Conclusions: There were no significant differences in long-term outcomes between subtypes α and β, although approximately 40 % developed liver failure during the postoperative course. Thus, close long-term follow-up is essential in type I/I cysts, regardless of the hepatic hilum morphology.

Keywords: Biliary atresia; Hepatic duct size; Hepatic hilum morphology; Long-term prognosis.

MeSH terms

  • Bile Duct Diseases / complications
  • Bile Duct Diseases / surgery
  • Bile Ducts
  • Biliary Atresia / complications
  • Biliary Atresia / surgery*
  • Cholangiography*
  • Cysts / complications*
  • Cysts / surgery
  • Female
  • Follow-Up Studies
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Postoperative Complications / diagnostic imaging*
  • Prognosis
  • Survival Analysis